The effect of levodopa may be reduced when Vitamin B6 is administered concomitantly.
Pyridoxine-Antagonists (e.g., Isoniazid, Cycloserine, Penicillamine, Hydralazine): The efficacy of Vitamin B6 (Pyridoxine) may be decreased.
Loop Diuretics (e.g., Furosemide): In long-term use, the blood level of Thiamine may be reduced.